BDBM10860 4-(aminomethyl)benzene-1-sulfonamide::CHEMBL419::MAFENIDE::aromatic sulfonamide compound 6::aromatic/heteroaromatic sulfonamide 5::hCA inhibitor, 9

SMILES NCc1ccc(cc1)S(N)(=O)=O

InChI Key InChIKey=TYMRLRRVMHJFTF-UHFFFAOYSA-N

Data  162 KI  7 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 10860   

TargetCarbonic anhydrase 6(Homo sapiens (Human))
Ondokuz Mayis University

LigandPNGBDBM10860(4-(aminomethyl)benzene-1-sulfonamide | CHEMBL419 |...)
Affinity DataKi:  1.01E+3nM ΔG°:  -8.17kcal/molepH: 7.4 T: 2°CAssay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 6(Homo sapiens (Human))
Ondokuz Mayis University

LigandPNGBDBM10860(4-(aminomethyl)benzene-1-sulfonamide | CHEMBL419 |...)
Affinity DataKi:  4.80E+3nMAssay Description:Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 6(Homo sapiens (Human))
Ondokuz Mayis University

LigandPNGBDBM10860(4-(aminomethyl)benzene-1-sulfonamide | CHEMBL419 |...)
Affinity DataKi:  4.80E+3nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 6(Homo sapiens (Human))
Ondokuz Mayis University

LigandPNGBDBM10860(4-(aminomethyl)benzene-1-sulfonamide | CHEMBL419 |...)
Affinity DataKi:  4.80E+3nMAssay Description:Inhibition of full length human recombinant CA VIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed